The provisional diagnostic criteria for the Dementia Questionnaire for Persons with Mental Retardation (DMR), developed during a prior study, were evaluated in a 5-year longitudinal follow-up of 33 elderly institutionalized persons, aged 70 years and over, and 45 institutionalized persons with Down's syndrome, aged 35 years and over, with no dementia in the diagnosis at initial evaluation. During the study period, dementia was diagnosed according to DSM-III-R criteria in five elderly subjects and five subjects with Down's syndrome, whereas a diagnosis of possible dementia was made in two elderly subjects and three subjects with Down's syndrome. A DMR diagnosis based on the criterion increase over time of the sum of cognitive scores (SCS) > or = 7 points and/or of the sum of social scores (SOS) > or = 5 points' resulted in a sensitivity of 100% for both groups and a specificity of 73% in the elderly sub-group and 75% in the sub-group with Down's syndrome, independent of the (premorbid) intellectual level. A diagnosis based on a single completion of the DMR, using available information on former performance levels, also produced favourable results in the present study. However, this diagnostic approach is certainly not recommended for studies of larger samples because of the use of different methods measuring functional levels and different standards for levels of intellectual disability.
Deb S, Braganza J. Deb S, et al. J Intellect Disabil Res. 1999 Oct;43 ( Pt 5):400-7. doi: 10.1046/j.1365-2788.1999.043005400.x. J Intellect Disabil Res. 1999. PMID: 10546964
Cooper SA, Prasher VP. Cooper SA, et al. J Intellect Disabil Res. 1998 Aug;42 ( Pt 4):293-300. doi: 10.1046/j.1365-2788.1998.00135.x. J Intellect Disabil Res. 1998. PMID: 9786444
Evenhuis HM. Evenhuis HM. J Intellect Disabil Res. 1992 Aug;36 ( Pt 4):337-47. doi: 10.1111/j.1365-2788.1992.tb00532.x. J Intellect Disabil Res. 1992. PMID: 1525439
Jeon YH, Sansoni J, Low LF, Chenoweth L, Zapart S, Sansoni E, Marosszeky N. Jeon YH, et al. Am J Geriatr Psychiatry. 2011 May;19(5):403-15. doi: 10.1097/JGP.0b013e3181ef7a0d. Am J Geriatr Psychiatry. 2011. PMID: 21522049 Review.
Pulsifer MB. Pulsifer MB. J Int Neuropsychol Soc. 1996 Mar;2(2):159-76. doi: 10.1017/s1355617700001016. J Int Neuropsychol Soc. 1996. PMID: 9375201 Review.
Altuna M, Estanga A, Garrido A, Saldias J, Cañada M, Echeverria M, Larrea JÁ, Ayo P, Fiz A, Muñoz M, Santa-Inés J, García-Landarte V, García-Sebastián M. Altuna M, et al. J Clin Med. 2024 Feb 17;13(4):1139. doi: 10.3390/jcm13041139. J Clin Med. 2024. PMID: 38398452 Free PMC article.
Stern AM, Van Pelt KL, Liu L, Anderson AK, Ostaszewski B, Mapstone M, O'Bryant S, Petersen ME, Christian BT, Handen BL, Selkoe DJ, Schmitt F, Head E; Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) investigators. Stern AM, et al. Alzheimers Dement. 2023 Dec;19(12):5755-5764. doi: 10.1002/alz.13382. Epub 2023 Jul 12. Alzheimers Dement. 2023. PMID: 37438872
Fleming V, Hom CL, Clare ICH, Hurd-Thomas SL, Krinsky-McHale S, Handen B, Hartley SL. Fleming V, et al. Int Rev Res Dev Disabil. 2022;62:227-263. doi: 10.1016/bs.irrdd.2022.05.006. Epub 2022 Jul 21. Int Rev Res Dev Disabil. 2022. PMID: 37396708 Free PMC article.
Delabar JM, Lagarde J, Fructuoso M, Mohammad A, Bottlaender M, Doran E, Lott I, Rivals I, Schmitt FA, Head E, Sarazin M, Potier MC. Delabar JM, et al. Transl Psychiatry. 2023 Apr 4;13(1):111. doi: 10.1038/s41398-023-02419-0. Transl Psychiatry. 2023. PMID: 37015911 Free PMC article.
Harp J, Koehl L, Van Pelt K, Head E, Jicha G, Robertson W, Lightner D, Lott I, Schmitt F. Harp J, et al. Neurol Clin Pract. 2022 Feb;12(1):6-13. doi: 10.1212/CPJ.0000000000001135. Neurol Clin Pract. 2022. PMID: 36157622 Free PMC article.